ID AFIX Toxin binder

Catalogue of ID AFIX Toxin binder

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Description

Introduction

Mycotoxins are secondary metabolites that are produced by molds (a species of fungi). They affect animal health which will lead to symptoms such as reduced feed intake, growth retardation, weakening of the immune system, increase in somatic cells of milk, nerve disorders, loss reproductive efficiency, and ultimately reduce the productivity. About 400 different species of mycotoxins have been identified so far, almost 30 of which have very toxic effects on the animals and Poultry. In fact, the properties of their toxic effects depends on fungal origin, chemical composition and their concentrations in the food ingredients. These compounds have considerable effects on the health of the livestock at very low concentrations. Mycotoxins are produced from three fungal species such as Aspergillus, Fusarium and Penicillium that can grow and proliferate in favorable environmental conditions (temperature, humidity, etc). There are six major classes of mycotoxins that are produced in feedstuffs such as; aflatoxins, trichothecenes, fumonisins, zearalenone, ochratoxin and ergot alkaloids which have synergistic effects on each other and lead to unavailability to nutritious food.


Strategies to reduce production and effects of mycotoxins

Generally, there are two strategies to prevent the production and effects of mycotoxins in feedstuffs. The first strategy is preventing the growth of mycotoxin-producing agents; as a result, the conditions for molds growth in feedstuffs will be disrupted using organic materials. According to reports, low pH of organic acids will severely limit the conditions for fungal growth. Therefore, reducing the growth of mycotoxin-producing agents will prevent their production. Moreover, it is not possible to inhibit the growth of all fungi with this method; consequently, the use of a complementary strategy to prevent the effects of mycotoxins appears to be necessary. One of the main strategies to reduce the effects of mycotoxins is using physiological methods and toxin absorbing compounds. As a result, toxins absorption from the gastrointestinal tract reduces and prevents the entry of these compounds into the blood and consequently into other organs of the body. Also, the use of biological methods such as fungi, bacteria, and enzymes in order to transform mycotoxins into harmless metabolites is another strategy to reduce the effects of mycotoxins.

In favorable conditions in terms of temperature, humidity and oxygen, molds immediately grow and proliferate on the feed and produce a large amount of toxins which are toxic for animal and enter into the liver to detoxify where they can accumulate and impose their destructive effects. In addition to antifungal compounds including organic acids to inhibit the growth of aspergillus and aflatoxin such as B1, B2, G1 and G2, ID'AFIX® has adsorbent compounds of mycotoxins (Toxin binder) with clay structure which remove them throughout the entire gastrointestinal tract by absorbing polar mycotoxins in feed. Therefore, the arrival of such toxic substances into the body and animal products can be prevented.

Absorption efficiency ID 'FIX® for various mycotoxins in vitro

Mycotoxin Absorption Removed Net absorption efficiency
Aflatoxin 92 12 80
T2 toxin 86 10 76
Zearalenone 58 18 40
Ochratoxin 70 36 34
Vomitoxin (Trichothecene) 59 10 49

ID 'AFIX® acts as a stable and insoluble complex in contact with digesta and excretes along with the feces.

 

Appearance of aflatoxin in cows’ milk consuming corns contaminated with aflatoxin with or without clay structures as toxin binderAppearance of aflatoxin in cows’ milk consuming corns contaminated with aflatoxin with or without clay structures as toxin binder

 

The mechanism of ID 'FIX®

  1. Organic acids limit the growth and proliferation of a wide variety of fungi and molds on feed in gredients during the storage procedures by creating the unfavorable conditions (reducing pH). Furthermore, reduction in pH will greatly increase the absorption capacity of toxins by toxin absorbing compounds such as Phyllosilicates. Moreover, organic acids will be considered as a source of absorbable energy through the digestive system without any harmful effects.
  2. Clay structures of phyllosilicate with its layered molecular system will trap mycotoxins.

Components of ID 'FIX®

Type of composition Performance
Sodium Format Preventing growth and proliferation of molds
Sodium diacetate Preventing growth and proliferation of molds
Calcium propionate Preventing growth and proliferation of molds
Sodium chloride Preventing growth and proliferation of molds
Clay compounds (clinoptilolite and sepiolite) Mycotoxins adsorbent
 Calcium carbonate carrier materials

 

Formulation and analysis of raw materials

  • Operational optimization based on standard tables of raw materials and standards of formulation for products in accordance with the requirements of each product
  • Use of qualified experts in the field of formulation, production, quality control and technical rules at the production line
  • Quick response in order to achieve the technical and economic advantages, using collective wisdom and doing sincere service
  • Interaction with customers to quickly respond to market needs
  • Benefiting from the latest date knowledge on the use of raw materials, including tests records and multiple sources of information
  • Cooperation with accredited laboratories such as IDAC laboratory in France
  • Permanent monitoring of the raw materials markets and relevant technological changes

 

System of quality and environmental control management

  • Quality management and food safety system under the certification of ISO 9001: 2000 and FAMI QS
  • Ensuring quality and safety of all products through the HACCP system
  • Commitment to the fundamental objectives in the field of risk control and continuous improvement of manufacturing processes and compliance with environmental requirements